Product Name: Tripropylene Glycol Methyl Ether
Chemical Formula: C10H22O4
Synonyms: TPGME, 1-Methoxy-2,4,6-trioxaoctane
CAS Number: 25498-49-1
Recommended Use: Solvent in coatings, cleaning fluids, inks, and chemical processing applications
Manufacturer/Distributor: Contact information appears on container label
Emergency Phone: See local company emergency contact details
Restrictions: Not suitable for food or pharmaceutical production
Classification: Eye Irritant (Category 2A), Skin Irritant (Category 3)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation. May cause mild skin irritation. Vapors may cause drowsiness or dizziness. Prolonged inhalation can irritate respiratory tract.
Pictogram: Exclamation mark
Precautionary Statements: Avoid breathing mist, vapors, or spray. Wear eye and face protection. Wash hands and exposed skin thoroughly after handling. Ensure good ventilation.
Chemical Name: Tripropylene Glycol Methyl Ether
Concentration: ≥98%
CAS Number: 25498-49-1
Impurities: Trace amounts of dipropylene glycol methyl ether and related glycols (≤2%)
Additives: Not present
Stabilizers: Not applied
Inhalation: Move affected person to fresh air, support breathing if necessary, seek medical help for persistent symptoms
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes; seek medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical advice
Ingestion: Rinse mouth, do not induce vomiting, drink small quantity of water if victim is conscious, contact medical professionals
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Specific Hazards: Vapors can form flammable mixtures with air under certain conditions. Thermal decomposition releases carbon oxides and other toxic fumes.
Protective Equipment: Self-contained breathing apparatus and full protective clothing recommended
Special Procedures: Avoid runoff from firefighting entering drains or watercourses. Cool containers exposed to flame with water spray.
Personal Protection: Wear proper gloves, eye protection, and clothing. Avoid breathing vapors.
Environmental Protection: Keep out of drains, surface, and ground water. Prevent large spills from entering sewers.
Cleanup Methods: Absorb with inert material (e.g., sand, earth), collect in chemical waste containers, ventilate the area well, wash spill site after material pickup is complete
Disposal: Dispose in compliance with local, regional, and national regulations
Handling Advice: Use only with adequate ventilation. Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke while working with the material.
Storage Conditions: Store tightly closed in original containers. Keep in cool, well-ventilated areas away from sunlight and incompatible materials.
Incompatible Materials: Strong oxidizers, acids, alkalis, and chlorinated compounds.
Other Precautions: Use spark-proof tools and explosion-proof equipment in high vapor areas.
Occupational Exposure Limits: ACGIH TLV: Not established; manufacturer recommends limiting air concentration < 50 ppm
Engineering Controls: Provide adequate exhaust ventilation; process enclosures recommended where feasible
Personal Protective Equipment: Chemical splash goggles, butyl rubber gloves, impervious apron, and shoes; use a NIOSH-approved respirator during insufficient ventilation scenarios
Hygiene Measures: Wash hands after handling. Remove contaminated clothing and clean before reuse. Do not allow eating or drinking in the work area.
Appearance: Colorless, clear liquid
Odor: Faint ether-like
Odor Threshold: Not readily established
pH: Not applicable
Melting Point/Freezing Point: -53°C (-63°F)
Boiling Point: 246°C (475°F)
Flash Point: 120°C (248°F) (closed cup)
Evaporation Rate: <0.1 (butyl acetate=1)
Flammability: Not classified as flammable per GHS, but will burn if heated
Vapor Pressure: 0.05 mmHg at 20°C
Vapor Density: 5.6 (air=1)
Relative Density: 0.97 g/cm³ at 20°C
Solubility: Soluble in water
Partition Coefficient (n-octanol/water): log Pow 0.56
Autoignition Temperature: 284°C (543°F)
Decomposition Temperature: Not well defined
Viscosity: 6.5 mPa·s at 25°C
Chemical Stability: Stable under normal ambient conditions and recommended storage guidelines
Conditions to Avoid: Heat, sparks, open flames, and exposure to direct sunlight
Incompatible Materials: Strong acids, strong bases, oxidizers, and certain chlorinated compounds may trigger hazardous reactions
Decomposition Products: Oxides of carbon, formaldehyde, and irritating fumes
Hazardous Polymerization: Will not occur under normal handling
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): 4000 mg/kg; Dermal LD50 (rabbit): >2000 mg/kg; Inhalation LC50 (rat, 4h): >400 ppm
Potential Health Effects: Skin irritation, serious eye irritation, mild respiratory distress if aerosol or vapor exposure prolonged; not believed to cause sensitization
Chronic Effects: No long-term effects identified in animal studies; not classified as carcinogenic, mutagenic, or teratogenic
Symptoms: Redness, discomfort, watering of eyes, headache, respiratory irritation
Sensitization: Not expected
Environmental Impact: Readily biodegradable; unlikely to persist in environment
Aquatic Toxicity: Fish (LC50, 96 h): 8690 mg/l; Daphnia (EC50, 48 h): 1919 mg/l; Algae (ErC50, 72 h): >1000 mg/l
Mobility in Soil: Mobile, may leach into groundwater if significant spills occur
Bioaccumulation Potential: Low, log Pow suggests poor potential
Other Adverse Effects: No known significant effects or critical hazards to aquatic life at expected environmental concentrations
Waste Treatment Methods: Collect and reclaim or dispose as hazardous waste according to federal, state, and local regulations
Product Disposal: Incineration is recommended for large quantities; small amounts may be absorbed and sent to licensed disposal facility if permitted
Container Handling: Triple-rinse containers before recycling or disposal
Sewage Disposal: Do not discharge to municipal sewage or natural water bodies
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as dangerous goods under DOT, ADR, IMDG, or IATA
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Avoid transporting with incompatible materials (e.g., strong acids, oxidizers). In case of bulk transport, use chemical-resistant containers and monitor for leaks or accidental releases.
Environmental Hazards: Not classified as marine pollutant
OSHA: Not specifically regulated under OSHA hazardous chemicals, but general safety rules apply
TSCA: Tripropylene Glycol Methyl Ether listed
REACH: Registered; subject to restrictions under Annex XVII if used in certain products
SARA Title III: Not listed as an extremely hazardous substance; not subject to reporting under SARA 302/304/313
California Proposition 65: Not listed
International Inventories: Listed in AICS (Australia), DSL (Canada), EINECS (EU), ENCS (Japan), and China IECSC
Other Regulations: Always check regional or national chemical inventories and local workplace safety standards for potential requirements specific to your location or usage context
