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Propylene Glycol Methyl Ether Acetate: More Than a Solvent

Historical Development

Propylene glycol methyl ether acetate, known across plenty of labs and factories as PGMEA, started grabbing attention in the mid-twentieth century. Manufacturers and chemists grew frustrated with heavy, slow-evaporating solvents. The search for something lighter but still tough enough for industrial work led to this molecule. The mixture of propylene glycol methyl ether and acetic acid brought not only a new solvent but also a new way of solving problems in coatings and electronics. Big paint brands and semiconductor giants didn’t just stumble on PGMEA—they dove into research, chasing faster drying times for paints and cleaners that wouldn’t gum up equipment. The spread of PGMEA traces back to shifting needs: the electronics boom, a desire for fewer odors in workplaces, and rising environmental scrutiny. I remember seeing colleagues, who once coughed through heady, acrid solvents, warm up to its more tolerable aroma—and the fact that it did the job without ruining their favorite shirts.

Product Overview

PGMEA appears as a colorless liquid. Sometimes, people working in small batch processing describe its smell as a little sweet—a faint reminder this stuff doesn’t just blitz your nose like old-school turpentine. Chemical suppliers list it under various catalog names, but all signal similar performance: high solvency for resins, effective as a cleaning agent, useful in ink and adhesive mixing. Its wide utility stems from a nifty combination of solubility and evaporation profile. Custom print shops and auto-body specialists prize it because it can cut through thick lacquer without leaving splotches or destroying surfaces.

Physical & Chemical Properties

PGMEA stands out with a molecular weight of about 132 and a boiling point hovering near 145°C. In my lab years, it handled gentle heating without drama, and even spilled on a bench, it didn’t eat through plastic or stain metal. Its flash point, around 42°C, puts it firmly in the flammable category, though it doesn’t light up at the drop of a spark the way some classic ethers might. Water solubility sits in the moderate range—enough to make cleanup easier than most paint thinners, but not so much it loses effectiveness in waterborne systems. Mixing PGMEA with esters or ketones opens the door to a broader range of tasks, and it keeps its cool in diverse temperature zones, holding up in both old, drafty factories and climate-controlled production lines.

Technical Specifications & Labeling

On the packaging, you’ll often spot CAS number 108-65-6, a marker chemists recognize. Regulatory teams prefer seeing this because it distinguishes PGMEA from dozens of close cousins. Most suppliers specify purity in the range of 99% or greater, and contamination by water, acidity, or other glycol ethers gets flagged quickly. SDS sheets advise against breathing in the vapors for long stretches, not only for comfort but also for staying inside workplace health limits. Bulk drums and laboratory bottles arrive with flammable and irritant labels, clear enough so even a seasoned worker, tired after the night shift, won’t miss the warning. Trace impurities, especially other glycol ethers, are called out since they can introduce unwanted reactivity in sensitive polymer or electronics work.

Preparation Method

The bulk of global PGMEA production relies on reacting propylene oxide with methoxypropanol, followed by esterifying the result with acetic acid. In a practical sense, operators watch reactor temperature and acid concentration closely—the yield drops when either swings out of range. Efficient processes reuse unreacted methoxypropanol, keeping costs in check and reducing waste. For shortages or high-purity demands, batch processes with tight control over temperature ramps and catalyst loading become the rule. Having spent time next to giant kettles, I’ve seen firsthand how the wrong sequence or hasty rush can send a perfect batch down the drain, so manufacturers lean into automation and sensor feedback.

Chemical Reactions & Modifications

PGMEA often goes under the radar as just a solvent, but under more aggressive conditions, it reacts with strong acids and bases, breaking down into smaller fragments or changing functional groups. In more specialized routes, it can act as a reactant, not just a medium, participating in transesterification where methoxy side chains jump to new partners, giving birth to a range of derivatives. In polymer chemistry, PGMEA sometimes gets caught up in crosslinking steps or as a leave-behind in cured films—meaning a trace of it can stick around and subtly alter final product toughness or gloss.

Synonyms & Product Names

Technical catalogs use a zoo of labels for this compound. You might glance at terms like 1-methoxy-2-propyl acetate, PGMEA, or PMA, and sometimes even less familiar ones in regional markets. In Japan and South Korea, supplier listings stick with the chemical name but tweak branding for electronics. For anyone hunting through shelves or web lists, catching all the synonyms prevents mixing up the wrong drum in fast-paced jobs. Older texts—particularly from Soviet or early European chemists—add a dash of confusion, so looking for product codes or CAS numbers gives peace of mind.

Safety & Operational Standards

Regulators in Europe, the US, and East Asia hand down similar rules: store PGMEA in cool, ventilated spaces, away from open flames and oxidizers. Closed transfer systems cut down on vapor exposure, especially during the summer rush when containers heat up in storage yards. Gloves and goggles rank high on the personal protective equipment list, and proper air monitoring keeps longer-term workers under exposure thresholds set by OSHA or REACH. In my early days, mentors taught that even foolproof-seeming setups spill sometimes—emergency showers and spill kits stand ready near blending stations. Fire drills rarely target the solvent bay, but old-timers know that flammable clouds linger long after a leak, so vigilance stays high during loading and unloading.

Application Area

PGMEA lines shelves in paint manufacturing, where it tackles both alkyd and acrylic resins, offering faster drying and smoother finishes. Ink makers love it for its ability to dissolve tough colorants that other solvents leave behind. In microelectronics, fab lines rely on PGMEA for photoresist solvent during the lithography process. Having walked those cleanrooms, I’ve noticed that equipment crews count on the predictable evaporation rate: slow enough to wet, fast enough to leave no trace, reducing defects on wafers. On top of that, PGMEA figures into adhesives, printing, and surface cleaners, especially wherever speed and control over residue matter. The automotive world counts on it to fade paint blends between panels. In every arena, reliability and consistent quality matter more than the chemistry—end users demand that a drum last month gives the same performance as one cracked open today.

Research & Development

Over recent years, research labs have chased safer glycol ethers, seeking lower toxicity with similar solvency. PGMEA stands among the better performers in this family, with ongoing work probing biodegradable versions or blends that maintain solvency with less environmental persistence. Analytical chemists track photodegradation and by-product formation, looking for new stabilizers or improved process control methods. Coatings scientists run trials—some brands try to squeeze every drop of performance out by tweaking resin and solvent ratios, or by coupling PGMEA with co-solvents for faster work at lower temperatures. In semiconductor centers, R&D teams spend hours dialing in purity, hunting down traces of metal or silicon that might compromise chip output. It’s clear that while PGMEA isn’t flashy, the incremental research adds up, driving cleaner, more stable output across industries that count on its unique profile.

Toxicity Research

Debates about PGMEA’s impact on health circle through academic journals, regulatory dockets, and shop floor breakrooms. Animal studies flag irritation at high doses, with lung and eye exposure topping the risk chart. Chronic overexposure links to liver effects in some rodent models, sparking manufacturers to tighten workplace limits. Human studies show relatively low acute toxicity, but exposure controls stay tight for pregnant workers and those with chemical sensitivities. Practical safety lines up with common sense: good airflow, proper gloves, no open flames. Disposal procedures stick to hazardous waste protocols. For all its relative mildness compared to legacy solvents like benzene or toluene, PGMEA carries that label of “handle with respect”—a lesson pounded home any time a technician oversteps and learns the hard way why the fume hood exists.

Future Prospects

As regulations tighten on volatile organics and worker safety standards ratchet up, PGMEA faces both challenge and opportunity. On one side, industries hunt for substitutes that cut total emissions or lower health risks, spurring new blends and biobased variants. On the other, research into nanomaterials and next-generation electronics drives up quality demands, pushing PGMEA into ultra-high purity territory. Smaller, more ethical manufacturers explore carbon-neutral production and cradle-to-grave tracking, aiming to shrink environmental impacts even further. As the next crop of scientists and operators step in, they’ll likely walk a line between old, trusted standards and the urge to reinvent, driving change with every batch, every drum, every new regulation that crosses the warehouse door.



What is Propylene Glycol Methyl Ether Acetate used for?

Why This Chemical Shows Up All Over Modern Industry

Propylene Glycol Methyl Ether Acetate, often abbreviated as PGMEA, pops up in plenty of corners where folks probably don’t expect it. Folks working in painting or electronics might already recognize the chemical, as it’s part of daily conversation in those circles. As someone who once wiped down freshly painted windows with a solvent-soaked rag, I can vouch for its unmistakable smell and strength. What surprises many is just how many fields rely on PGMEA’s unique ability to dissolve, clean, or act as a carrier. Understanding its reach helps to see why industries keep it stocked and why governments keep an eye on its environmental footprint.

Painters and Coaters: Trusting in Quick, Even Results

Commercial paint doesn’t flow smoothly out of the can by accident. Factories demand speed and consistency, whether making car exteriors or appliance shells. PGMEA gets added so that paint sprays evenly and dries at the right rate. Car companies, for example, can’t gamble on streaks or unexpected drying times — PGMEA gives them better control. Without it, paint might clump, spit, or turn into a sticky mess before finishing.

If you’ve ever walked through a freshly built house, you’ve probably smelled PGMEA in the air, since it’s often part of the formula for wood stains and clear finishes. Its low odor compared to some older solvents helps create a safer environment for workers and residents, and its nature as a “medium evaporator” keeps finishes from bubbling or running. More construction companies want consistent, high-quality appearance, and PGMEA quietly supplies that.

Electronics Manufacturing: Cleaning Up the Details

Making circuit boards prompts much fuss about precision and “no residue left behind.” In that setting, PGMEA acts as a developer for photoresists during semiconductor processing. Picture a microchip with thousands of impossibly narrow lines, each one etched and patterned by chemicals that wash away parts of a coating to reveal the circuit beneath. Mess up that step, and the chip fails. Here, PGMEA gives companies the control to remove just what they need and leave behind clean, workable surfaces.

Phone screens, computer monitors, and touch panels also receive a helping hand from this solvent. Behind each sleek glass sheet lies a stack of specialized coatings applied in clean rooms. PGMEA helps lay down and smooth out those ultra-thin layers. It fights unwanted residues so manufacturers don’t send out screen after screen with visual flaws or touch glitches.

Environmental and Safety Questions

Of course, regular exposure to solvents isn’t without risk. Factory workers know to treat PGMEA with respect: goggles, gloves, and even respirators often come out when the big drums are opened. Breathing in too much vapor or getting it on skin can irritate or cause real harm. Regulations set strict rules on ventilation in enclosed spaces. Every worker I’ve talked to about industrial chemicals knows someone with a story about failing to properly suit up.

On top of that, manufacturers face growing pressure on how they dispose of chemical-laden waste. Local governments frown on any solvent winding up in waterways, and costly spill cleanups motivate companies to manage tanks with care. Some research pushes for greener alternatives, but replacements struggle to balance safe handling, cost, and technical performance.

The Push for Safer Practices

Training employees on chemical safety shouldn't stop at the basics. Factories that invest in modern handling systems, improved ventilation, and routine air quality testing protect both their workforce and the neighborhood. As someone who’s worked in a busy production line, I’ve seen productivity climb and accident rates fall just by improving air extraction or switching up old habits. Educating on hazards and looking for possible substitutions matters at every level.

PGMEA isn’t going anywhere soon. It’s deeply woven into electronics, automotive paint shops, and wood finishing. Responsibility falls on both companies and regulators to keep workers safe and to reduce chemical leaks. Change may come slowly, but step by step, smarter use and safer environments will benefit everyone involved with this humble solvent.

What are the safety precautions when handling Propylene Glycol Methyl Ether Acetate?

I’ve seen workshops where floors stay sticky from spills, noses sting from harsh fumes, and gloves tear halfway through a job. Folks don’t always treat chemicals with much respect—especially ones with long names like Propylene Glycol Methyl Ether Acetate (PGMEA). For anyone who spends time around paints, inks, or cleaners, this stuff becomes an old acquaintance. The familiarity can breed shortcuts, so it’s worth spelling out the risks and the simple routines that keep everyone walking out at the end of a shift in good shape.

Why Bother with Safety?

PGMEA stays clear, flows easy, and acts like so many other solvents at first glance. Breathe in too much of the vapor and dizziness starts slipping in. Unprotected skin absorbs some of it, triggering irritation over time. Garments offer only a false sense of security if they’re thin or torn. Even a bit splashing in the eyes sends folks stumbling for the eyewash station faster than they’d like to admit. Incidents like these don’t need horror stories—just one headache that lingers for days or a patch of chapped skin is enough to learn respect for the stuff.

Get the Gear Right

Many jump straight to gloves, sometimes grabbing whatever's nearest. Nitrile beats out latex or the cheap disposable kind. They last longer and block leaks better. Wearing safety goggles isn't just for those who handle big drums of the product. Even pouring smaller amounts can lead to splashes, so anyone mixing or cleaning up needs to protect the eyes. Aprons made of strong, chemical-resistant material—heavy rubber or coated fabric—keep splashes off the skin and spare people from scrubbing off sticky residues for hours afterward.

Ventilate Like You Mean It

One open window won’t clear out solvent fumes. Fans close to the work zone do a far better job. Local exhaust, such as hoods or ducted vent systems, pulls the vapor away before it drifts upward. Anyone who’s spent time in a cramped room with one of these solvents knows how fast your nose tells you when air stops moving. In larger shops, air filters made for volatile chemicals help, but nothing beats fresh air exchange. If working in a small area or underground, I always double check the airflow before I start. The feeling in your lungs after good ventilation remains totally different from stale, recycled air humming through an old filter.

Keep Ignition Far Away

PGMEA catches fire way easier than water or soap. Sparks from worn-out power tools, lighters forgotten in somebody’s pocket, or even static from certain clothing can surprise you. Smoking needs to stay outside. Any electrical equipment needs proper housings that don’t create sparks, and folks filling containers should always ground them so static won’t leap at the wrong moment. At home, telling neighbors or housemates not to bring open flames near the shop is half prevention right there.

Clean Up Spills Right Away

Wiping with a rag doesn’t cut it for solvent spills. Absorbent pads meant for chemicals work better, and containers for cleanup waste stay far from anything hot. I label mine clearly and hand them off to the people who deal with hazardous waste. So many workshops let the stuff pile up in corners, then scramble when the inspector drops by. Cleaning up as you go keeps everyone safer in the long run.

Storing It Properly

PGMEA stores best in sealed, labeled containers set on spill trays. Don’t pack them into shelves with food or regular cleaning supplies. The legal requirements may read dry, but for me, it boils down to keeping the workspace where I work, not where I eat lunch. Drums and cans get checked for rust or leaks, and nothing ever goes under direct sunlight or near heat sources.

These steps don’t demand fancy systems. They rely on habits and a touch of respect for something that looks dull but can turn dangerous if you turn your back. Most places run smoother once these bits become second nature, and nobody has to find out the hard way what skipping a step costs.

Is Propylene Glycol Methyl Ether Acetate hazardous to health or the environment?

Digging into the Chemical’s Real Impact

Propylene glycol methyl ether acetate—people in manufacturing circles simply call it PGMEA—doesn't grab headlines, but it flows through factories every day. It's clear, has a mild smell, and finds its way into paints, inks, and cleaning agents. Most folks outside these industries have no idea they cross paths with this solvent, often through finished products.

For people who work with PGMEA, breathing in its vapors can irritate the nose and throat pretty quickly. I’ve talked to painters and shop-floor workers who say that after a full shift around poorly ventilated mixing tanks, they start to feel dizzy or get lightheaded. Short-term exposure usually passes with some fresh air, but stay in that environment long enough and small problems grow. Repeated contact seems to dry out the skin, and the headaches stick around. In concentrated settings, the fumes can spark fires, so crews need to keep their wits about them.

Looking at the Science and Straightforward Risks

Studies point out PGMEA doesn’t cause cancer, but it will mess with your system at higher doses. California’s OEHHA and the European Chemicals Agency both note reproductive risks at exposure above workplace safety limits. Nobody wants solvents in the bloodstream, and this is a chemical that slips through the skin and lungs. Because it evaporates fast, open containers can build up unsafe air in short order. Goggle and glove rules exist for good reason.

What about the wider world? Factories have improved their waste-handling, yet PGMEA spreads easily in water and the soil if containers leak. It doesn’t stick around like old-school pollutants, but as it breaks down, it can stress out fish and microscopic life. In city air, sunlight breaks it apart, but the breakdown kicks off other chemical reactions. These reactions don’t wreck the ozone or choke whole neighborhoods, yet they add up when lots of plants use PGMEA without modern scrubbers.

Are There Sensible Fixes?

Shielding people is simple on paper. Open the windows (or more often, get a real exhaust system), hand out nitrile gloves and snug-fitting goggles, swap to closed-batch mixing lines. I've seen small companies chase this paper trail just because a can tipped over last year and sent half the team to the nurse. Every mishap leads to another round of safety training and sometimes a bit of eye-rolling, but the close calls drop.

On the environmental front, PGMEA isn’t the worst actor, but smart engineering works wonders. Keeping tanks sealed, using spill pans, and treating water runoff through carbon filters serve as battle-tested moves. Cities can require permits and air monitoring for companies that use this solvent, giving neighbors clear info so they can pressure for better practices if needed.

If you work where PGMEA flows, don’t take it lightly just because it’s less famous than lead or asbestos. Clean-up routines, protective gear, and investment in safer substitutes all chip away at the risks. In real shops, mistakes happen—so making the fixes easy and automatic takes the guesswork out of it. For companies and communities, the solutions cost less in the long run than ignoring the potential for health headaches and environmental hiccups.

What are the storage and transportation requirements for Propylene Glycol Methyl Ether Acetate?

A Chemical With Specific Needs

Propylene Glycol Methyl Ether Acetate lands in a lot of workshops, often near where paints and coatings get mixed up. Over the years, its sharp smell and clear, runny texture have made a lasting impression. This isn’t something you can just shove in any spare drum or ship with the regular cans of paint thinners. There’s a real reason for the extra attention: safety and quality hinge on a few details you can’t ignore.

Keep It Cool, Keep It Steady

This solvent likes a cool, shady corner. Get it too warm, and vapor builds up quick—high flammability means you’re courting risks. Anything above 40°C starts to spell trouble, so temperature control needs real focus. Even the best packaging can’t hold back pressure if the storage spot sits in a sunbeam or beside a heat vent all day.

Ventilation counts for a lot. Fumes find their way out of even the best valves and seals. Without steady air movement, those fumes build up and set the stage for fire or health hazards. I’ve seen too many site inspections where the solvent drum rests in a locked shed with barely a cracked window, and that lack of airflow leaves crews vulnerable. A facility with open flow—think high ceilings, fans, or even exhaust systems—keeps things much safer than the dusty corner of an old warehouse.

Keep It Clean, Keep It Dry

Water and dust sneak into containers. Few things ruin a batch of solvent faster than a little condensation sliding down the inside of a metal drum. Moisture kick-starts corrosion, and it’s no fun fishing chunks of rust out of what should be pure solvent. Humidity and water leaks turn a safe workspace into a project for the local fire department. PGMEs sit happiest on pallets or raised racks, kept away from floor spills and puddles, with the lids sealed tight between uses.

You can’t chalk this all up to the safety manager’s checklist. Anyone who’s handled a delivery of drums knows the heartbreak when a busted seal after heavy rain means unsalvageable material. This isn’t a rare case—the basics, like checking for dents and rust before accepting a shipment or storage, save money and trouble.

Separation Prevents Surprises

Mixing PGMEs with something reactive, even accidentally, can trigger headaches—sometimes literal ones due to fumes, sometimes the kind that hits when paperwork arrives after a near-miss. Acids and bases live in a different neighborhood. The fire code spells it out, but nothing drives the point home like a chemical spill during a busy shift. I’ve watched teams pore over lists of chemicals in the storeroom to double-check they don’t stack solvents next to paint hardeners or bleach.

Transport: Shake-Free and Leak-Proof

Getting this solvent from point A to B looks simple, but the route matters. Shipping bumpy back roads in a poorly loaded truck can raise pressure, stress seams, and rattle loose the clamps meant to keep everything tight. The best shipments I’ve dealt with used UN-approved drums, carefully loaded and strapped, with enough separation from other chemicals to keep things predictable.

Paperwork isn’t just a formality—every driver needs a manifest, labeling has to match the drum contents, and emergency contact info should be easy to read. Skipping these details creates confusion fast if something goes off script during transit. Flammable liquid placards warn everyone what’s inside. In a real spill, those big red diamond labels save time and lives.

Practical Solutions From Experience

Training the team works better than hoping the posted rules get noticed. People remember a demonstration showing how quick a leak becomes trouble. Routine checks—daily or weekly—catch most issues before they become disasters. Spare gaskets, dry rags, extra labels: having these on hand may sound like small details, but the small stuff almost always matters more than the expensive fixes after an accident.

Simple routines—keep it cool, keep it apart from the wrong neighbors, keep it off the ground, and keep everyone involved—form the backbone of safe chemical management. No magic tricks, just everyday vigilance paying off.

How should spills or leaks of Propylene Glycol Methyl Ether Acetate be managed?

Spills Happen—Quick Action Matters More

Propylene glycol methyl ether acetate (PGMEA) gives off the familiar smell you’ll find in paints and electronics manufacturing. Most folks never think about it, but for those working around this solvent, spill response isn’t just routine paperwork. It’s a genuine risk, especially because this chemical evaporates fast and carries health hazards. Skin contact can bring rashes. Breathing the vapors causes headaches and nausea. If a leak happens, you have to act right away because waiting only helps that evaporation process along, spreading the bad news further.

No Shortcuts With Protective Gear

Once a spill hits the floor, grabbing gloves and goggles might seem obvious, but it’s surprising how many still shortcut these basics. My own time in a factory setting showed me folks will sometimes reach for paper towels without even thinking about their skin. Real PPE—nitrile gloves, a splash apron, and chemical goggles—keeps the chemical from finding its way onto your skin or in your eyes. Even if someone thinks the amount spilled is small, the fumes still get in your system if a mask gets skipped.

Ventilation Changes the Game

Letting a spill stir up inside a room with little air movement only amps up the danger. I remember one case in a small maintenance room where a lack of fans sent everyone outside with headaches. Spills demand open windows, exhaust fans pointed at the mess, and quick evacuation if the smell hits hard. Just cracking a door won’t cut it—every ounce of airflow you can muster pulls those vapors away from people in a hurry.

Cleanup Isn’t Just About Absorbing

Some grab the nearest mop or sawdust. In real life, absorbent pads labeled “chemical” actually make a difference. I’ve seen people rely on kitty litter or old rags, only to spread contaminants or miss spots where the liquid seeps underneath machinery. Chemical absorbents soak up volatile solvents much better. Scooping and sealing the pads in double-bagged containers or metal drums avoids future leaks at the waste site. If you toss the wasted material with regular garbage, everyone down the line inherits your problem. That’s not fair to the next guy, nor is it legal. Label the waste container with what’s inside—no room for guessing on collection day.

Reporting Keeps Folks Honest

All the best cleanup routines mean nothing if folks hide mistakes. Fear of blame stops people from speaking up—but the next shift worker pays the price. Honest reporting builds trust and lets supervisors track trouble spots. My experience says clear, shame-free procedures around spills encourage people to flag even the smallest leaks. I’ve watched teams improve their workspace because everyone took the process seriously, not personally.

Training Builds a Safer Culture

None of this sticks if workers haven’t practiced what to do. Walking through spill drills, rehearsing where supplies sit, and understanding the chemical’s symptoms makes a world of difference. I remember a new hire who hesitated in an emergency—training could have saved precious seconds. Regular refresher sessions honestly separate prepared teams from winging it.

Better Design Prevents Future Spills

The more time I’ve spent around chemicals, the more obvious design flaws become. Drums stored on worn plastic pallets, unlabeled containers stashed in dark corners, or pipes without clear shutoff valves always invite trouble. Investing in strong shelving, secondary containment trays, and good labeling tackles the problem at its roots. Even the best responders will tell you that stopping spills in the first place beats every cleanup protocol combined.

Propylene Glycol Methyl Ether Acetate
Propylene Glycol Methyl Ether Acetate
Names
Preferred IUPAC name 1-methoxypropan-2-yl acetate
Other names 1-Methoxy-2-propanyl acetate
PGMEA
Propylene glycol monomethyl ether acetate
2-Methoxy-1-methylethyl acetate
Dowanol PMA
Arcosolv PMA
Pronunciation /ˈprəʊpɪliːn ˈɡlaɪkɒl ˈmɛθəl ˈɛθər əˈsiːteɪt/
Identifiers
CAS Number 108-65-6
3D model (JSmol) Isomeric SMILES string for **Propylene Glycol Methyl Ether Acetate** (also known as **PGMEA**): ``` CCOC(C)COC(=O)C ``` This string can be used in JSmol or other molecular visualization tools to generate a 3D model.
Beilstein Reference 636301
ChEBI CHEBI:8817
ChEMBL CHEMBL159190
ChemSpider 7661
DrugBank DB14183
ECHA InfoCard 03d9a677-b0c9-4617-8a7f-3de7ee7a396b
EC Number 108-65-6
Gmelin Reference 9037
KEGG C19616
MeSH D017355
PubChem CID 7927
RTECS number AO8925000
UNII 9U6LF4D5SZ
UN number UN3272
Properties
Chemical formula C8H16O3
Molar mass 132.16 g/mol
Appearance Colorless transparent liquid
Odor Sweet.
Density 0.966 g/cm3
Solubility in water Miscible
log P 0.43
Vapor pressure 0.49 mmHg (20°C)
Acidity (pKa) pKa ≈ 15.5
Basicity (pKb) 8.20
Magnetic susceptibility (χ) -7.63×10⁻⁶
Refractive index (nD) 1.400
Viscosity 0.43 mPa·s (at 25°C)
Dipole moment 2.93 D
Thermochemistry
Std molar entropy (S⦵298) 362.0 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -576.5 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -3276 kJ·mol⁻¹
Pharmacology
ATC code D02AX
Hazards
GHS labelling GHS labelling: Danger; H226, H336, P210, P261, P304+P340, P312, P403+P233
Pictograms GHS02,GHS07
Signal word Warning
Hazard statements H226, H336
Precautionary statements P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P312, P370+P378, P403+P235, P501
Flash point 46 °C
Autoignition temperature 315 °C (599 °F)
Explosive limits 1.5% - 7.0%
Lethal dose or concentration LD50 (oral, rat): 6,190 mg/kg
LD50 (median dose) 6,400 mg/kg (rat, oral)
NIOSH PM 179
PEL (Permissible) PEL: 100 ppm (as an 8-hour TWA)
REL (Recommended) 100 ppm, 540 mg/m3
Related compounds
Related compounds Propylene glycol methyl ether
Propylene glycol
Methyl acetate
Ethylene glycol methyl ether acetate
Dipropylene glycol methyl ether acetate
Propylene glycol ethyl ether acetate
Ethylene glycol dimethyl ether