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Material Safety Data Sheet: Methyl Cellosolve

Identification

Product Name: Methyl Cellosolve
Chemical Name: 2-Methoxyethanol
Synonyms: Ethylene glycol monomethyl ether
CAS Number: 109-86-4
Recommended Use: Solvent in coatings, inks, cleaners, chemical manufacturing
Manufacturer: Various chemical producers
Emergency Contact Number: Local or national poison control center

Hazard Identification

GHS Classification: Flammable Liquid (Category 3), Acute Toxicity (Category 4, oral, dermal, inhalation), Reproductive Toxicity (Category 1B), Eye Irritation (Category 2A), Specific Target Organ Toxicity (single and repeated exposure)
Label Elements: Signal word: Danger; pictograms: flame, health hazard, exclamation mark
Hazards: Causes serious eye irritation, may damage fertility or the unborn child, harmful if swallowed, in contact with skin, or inhaled, flammable liquid and vapor
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Precautionary Statements: Avoid breathing vapors or mist, use protective gloves and eye protection, keep away from heat/sparks/open flames

Composition / Information on Ingredients

Chemical: 2-Methoxyethanol
Concentration: Typically above 99%
Impurities or stabilizing additives: Not common in analytical grade
Molecular Formula: C3H8O2
Molecular Weight: 76.09 g/mol

First Aid Measures

Inhalation: Move the person to fresh air, offer oxygen if breathing is difficult, call a physician
Skin Contact: Remove contaminated clothing, wash affected area with plenty of water and soap, seek medical attention for persistent irritation
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids to thoroughly flush, get medical help
Ingestion: Do not induce vomiting, rinse mouth with water, call a poison center or doctor immediately
Most Important Symptoms: Eye irritation, dizziness, drowsiness, nausea, reproductive effects, central nervous system depression

Fire-Fighting Measures

Suitable Extinguishing Media: Alcohol-resistant foam, dry powder, carbon dioxide, water spray
Unsuitable Media: Direct water jet can spread liquid
Specific Hazards: Vapors can form explosive mixtures with air, toxic gases upon combustion (carbon monoxide, carbon dioxide)
Protective Equipment: Full firefighting turn-out gear, self-contained breathing apparatus
Advice for Firefighters: Evacuate area, fight fire from safe distance, prevent run-off from contaminating water sources

Accidental Release Measures

Personal Precautions: Evacuate personnel to safe area, ventilate area, avoid breathing vapors
Protective Equipment: Gloves, chemical goggles, protective clothing, respiratory protection
Environmental Precautions: Prevent entry to drains, surface waters, and soil
Methods for Containment: Stop leak if safe, absorb spill with inert material like sand or earth
Cleaning Techniques: Collect in suitable, labeled, sealed containers for disposal, flush area with water after cleanup

Handling and Storage

Handling: Use only in well-ventilated areas, keep containers tightly closed, avoid breathing vapors, avoid skin and eye contact, wash hands thoroughly after use
Storage: Store in cool, dry, well-ventilated place away from heat sources and incompatible materials like strong acids, bases, and oxidizing agents
Packaging: Use corrosion-resistant containers, double containment preferred
Incompatibilities: Do not mix with alkali metals, anhydrides, strong oxidizers

Exposure Controls and Personal Protection

Occupational Exposure Limits: OSHA PEL: 25 ppm TWA, ACGIH TLV: 0.1 ppm TWA
Engineering Controls: Use local exhaust and general ventilation to control vapor levels
Personal Protective Equipment: Chemical-resistant gloves (nitrile, butyl rubber), goggles or face shield, flame-resistant lab coat, respirator in absence of ventilation
Hygiene Measures: Remove contaminated clothing, avoid eating and drinking in work area, wash thoroughly before breaks

Physical and Chemical Properties

Appearance: Clear, colorless liquid
Odor: Mild, ether-like odor
Melting Point: -85°C
Boiling Point: 124°C
Flash Point: 39°C (closed cup)
Evaporation Rate: Slow
Flammability: Flammable
Vapor Pressure: 8 mmHg at 20°C
Solubility: Miscible with water
Volatility: High
Density: 0.964 g/cm³ at 20°C
Viscosity: 1.7 mPa·s at 20°C

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: Can react with strong oxidizers producing heat and toxic fumes
Conditions to Avoid: Heat, sparks, open flames, static discharge
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, formaldehyde
Incompatible Materials: Strong acids, bases, oxidizing agents, reducing agents, alkali metals

Toxicological Information

Acute Toxicity: LD50 Oral (rat): 1200 mg/kg, LD50 Dermal (rabbit): 1280 mg/kg
Inhalation: Can irritate respiratory tract, central nervous system effects (headache, dizziness, drowsiness, nausea)
Skin Contact: Absorbed through skin, may cause irritation and systemic toxicity
Eye Contact: Serious irritation, redness, watering
Chronic Effects: Long-term exposure linked to birth defects, fertility impairment, damage to blood and bone marrow
Other Health Effects: Possible kidney and liver damage on prolonged exposure

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms at high concentrations, LC50 (fish, 96h): ~5000 mg/L
Mobility: Mobile in soil, significant potential for groundwater contamination
Persistence and Degradability: Readily biodegradable, but environmental buildup possible with large or repeated releases
Bioaccumulation Potential: Low
Other Effects: Prevent large amounts from entering waterways to avoid ecosystem disruption

Disposal Considerations

Waste Disposal Methods: Incineration at approved facility or disposal in accordance with local, state, and federal regulations
Contaminated Packaging: Rinse thoroughly before recycling or disposal
Disposal Precautions: Always keep materials away from drains and natural water sources, do not dump in garbage or storm sewers, use clearly labeled hazardous waste containers, involve licensed waste disposal contractor if needed

Transport Information

UN Number: 1188
Proper Shipping Name: Ethylene glycol monomethyl ether
Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labeling Requirements: Flammable liquid label
Transport Precautions: Protect from physical damage, keep containers closed and upright, avoid direct sunlight

Regulatory Information

OSHA: Regulated hazardous chemical, subject to workplace safety training and labeling
EPA: Listed as hazardous air pollutant under Clean Air Act
SARA Title III: Section 313 toxic chemical; subject to reporting requirements
TSCA: Listed, restrictions apply to use and import
California Proposition 65: Listed as known reproductive toxin
Other Regulations: International transport regulations (IATA, IMDG) apply due to flammability and toxicity, safety data sheet requirements aligned with GHS labeling standards